These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [GABA-ergic system components and lipid peroxidation in acute exogenous acrylonitrile poisoning].
    Author: Ivanov VV, Alyshanskiĭ AM.
    Journal: Biull Eksp Biol Med; 1982 Jul; 94(7):40-3. PubMed ID: 7126824.
    Abstract:
    A study was made of the content of biogenic amines as of a number of functions of the plasma membrane of hepatocytes and activity of lipid peroxidation during acute acrylonitrile poisoning. This industrial monomer stimulated all the parts of the sympatho-adrenal system and caused a reduction of the GABA level that is likely to be a consequence of inhibition of glutamate decarboxylase biosynthesis. Moreover, it was found that barrier and regulatory functions of the hepatocyte membrane were impaired. Accumulation of diene conjugates and protective action of alpha-tocopherol that prevented the development of the discovered stressor alterations point to a possible pathogenetic relationship between the disorders seen and poison-induced lipid peroxidation.
    [Abstract] [Full Text] [Related] [New Search]