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  • Title: Agglutination of isolated rat bladder cells by lectins after administration of N-butyl-N-(4-hydroxybutyl) nitrosamine.
    Author: You-Ren W, Kakizoe T, Kawachi T, Sugimura T.
    Journal: Cancer Lett; 1982; 16(2):121-8. PubMed ID: 7127275.
    Abstract:
    Lectins, concanavalin A (Con A), wheat germ agglutinin (WGA), and Ricinus communis agglutinin (RCA) were used for agglutination of isolated rat bladder cells after administration of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). The results showed that WGA and RCA, as well as Con A, agglutinated rat bladder cells during the early stage of bladder carcinogenesis. The agglutinations by the 3 kinds of lectins were different; WGA and Con a agglutinated only BBN-treated cells but RCA agglutinated both BBN-membrane alterations during the early phase of bladder carcinogenesis.
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