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  • Title: Effect of nifedipine on digoxin kinetics in healthy subjects.
    Author: Pedersen KE, Dorph-Pedersen A, Hvidt S, Klitgaard NA, Kjaer K, Nielsen-Kudsk F.
    Journal: Clin Pharmacol Ther; 1982 Nov; 32(5):562-5. PubMed ID: 7127997.
    Abstract:
    Verapamil has been shown to reduce total-body digoxin clearance by 35% due to impairments of both renal and extrarenal clearances. Our study was undertaken to evaluate the influence of the related calcium antagonist nifedipine on single-dose kinetics. Nifedipine increased extrarenal clearance of digoxin from 1.09 +/- 0.30(SD) to 1.45 +/- 0.23 ml/min/kg (P less than 0.05) and reduced the total urinary recovery of the drug from 69.2% +/- 5.9(SD) to 64.3% +/- 5.2 (P less than 0.05). There were no significant changes in renal digoxin clearance, distribution, or biological half-life or in digoxin distribution volumes during nifedipine coadministration.
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