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  • Title: The effects of gliclazide on platelet function in patients with diabetes mellitus.
    Author: Violi F, De Mattia GC, Alessandri C, Perrone A, Vezza E.
    Journal: Curr Med Res Opin; 1982; 8(3):200-3. PubMed ID: 7128193.
    Abstract:
    Eighteen diabetic patients with abnormal platelet function were treated for 1 month with gliclazide (80 to 160 mg/day). Platelet aggregation, circulating beta-thromboglobulin levels and platelet malondialdehyde concentrations were significantly reduced after 30 (but not 15) days of treatment. Although fasting and post-prandial glycaemia significantly improved in these patients, similar changes in platelet function were noted in 5 other patients in whom glycaemia did not change. Gliclazide therapy, therefore, brought about an improvement in platelet function and a reduction activation in the thromboxane metabolic pathway, possibly by a direct on the platelets.
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