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  • Title: [Effect of sombrevin and sodium oxybutyrate on the excitable membranes of a frog neuromuscular preparation].
    Author: Bender KI, Seliverstov GA.
    Journal: Farmakol Toksikol; 1982; 45(4):30-4. PubMed ID: 7128782.
    Abstract:
    Comparative evaluation of the effect of sombrevine and sodium hydroxybutyrate on the frog neuromuscular preparation with the use of intra- and exocellular recording of the drug-induced electrophysiological effects has shown that sombrevine inhibits the function of the excitable cell membranes whatever their functional specificity at the expense of interaction with lipid matrix of the membranes. The action of sodium hydroxybutyrate is determined by diminution of anion conduction of the excitable membranes and by an increase in their electrical resistance, which determines the hyperpolarizing action and stimulation of neuromuscular transmission in the frog skeletal muscle.
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