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  • Title: Oral pulse prednisone therapy in the treatment of HBsAg negative chronic active hepatitis.
    Author: Chase WF, Winn RE, Mayes GR.
    Journal: Gastroenterology; 1982 Dec; 83(6):1292-6. PubMed ID: 7129032.
    Abstract:
    A young woman with hepatitis B surface antigen negative chronic active hepatitis and hypergammaglobulinemia was treated successfully with oral pulse steroid therapy consisting of prednisone, 90 mg/day, given in repeated 3--5-day courses at 3--4-wk intervals. This approach, which is hypothetically founded on the ability of steroids to cause prolonged inhibition of immunoglobulin G synthesis and proposed mechanisms of hepatocellular damage in chronic active hepatitis, permitted complete clinical, chemical, and histologic remission without morbidity. Oral pulse prednisone therapy deserves further study as a possible adjunct or alternative to existing methods of managing hepatitis B surface antigen negative chronic active hepatitis associated with hypergammaglobulinemia.
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