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  • Title: Toxic shock syndrome or toxic epidermal necrolysis? Case reports showing clinical similarity and histologic separation.
    Author: Hurwitz RM, Rivera HP, Gooch MH, Slama TG, Handt A, Weiss J.
    Journal: J Am Acad Dermatol; 1982 Aug; 7(2):246-54. PubMed ID: 7130484.
    Abstract:
    A case of toxic shock syndrome and a case of drug-induced toxic epidermal necrolysis with renal involvement are described. The two patients had similar early clinical manifestations and therefore posed a difficult differential diagnosis. Diagnostic distinction is important because therapy differs considerably. A skin biopsy in each case proved helpful in establishing the correct diagnosis, since there appears to be a different histologic pattern for each condition: superficial perivascular dermatitis for toxic shock syndrome and an interface dermatitis for toxic epidermal necrolysis.
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