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  • Title: [Serum sex steroid hormones in women with aging, and in the patients of climacteric syndrome and squamous cell carcinoma of the uterus].
    Author: Nishimura T.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1982 Sep; 34(9):1549-58. PubMed ID: 7130776.
    Abstract:
    The endocrinological studies were conducted in 116 normal women with aging, 16 women with climacteric syndrome and 31 patients of cervical cancer. The levels of serum estrone, estradiol and estriol had a tendency of gradual decline after the age of 40, and decreased rapidly 3 years after menopause, but still remained in a certain level thereafter throughout the senile period. The serum progesterone tended to decrease after the age of 40. While the serum testosterone showed no particular change before menopause, began to decrease after menopause. Women with climacteric syndrome were found to have a significant low serum estrogen and testosterone than in normal women, while a relative low tendency of serum progesterone in the premenopausal women of climacteric syndrome were observed. There was a relative high serum progesterone and testosterone found in adult and premenopausal patients of cervical cancer than in normal women, but showed no any difference of estrogen between them. The serum estrogen/testosterone ratio in cervical cancer group, was higher than that in the normal. Serum estrogen from the ovarian plexus was found several ten times higher than that in the iliac artery. However, progesterone and testosterone were found a slightly higher in the former.
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