These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Megakaryocytopoiesis and granulopoiesis following cyclophosphamide.
    Author: Petursson SR, Chervenick PA.
    Journal: J Lab Clin Med; 1982 Nov; 100(5):682-94. PubMed ID: 7130827.
    Abstract:
    CTX is a marrow-suppressant drug that has been reported to have a "sparing effect" on blood platelets. To investigate whether CTX spares platelet precursor cells as well as platelets, blood platelets, megakaryocytes, and CFU-M were studied in mice after the injection of CTX. The soft gel in vitro culture system was utilized to assay for CFU-M in marrow and spleen. CTX produced only a mild thrombocytopenia to 88% to 95% of control values. This was followed by a modest, but significant thrombocytosis of 120% of controls on day 10. Despite the slight effect on blood platelets, striking changes were observed in megakaryocytes and CFU-M. Megakaryocytes and CFU-M were decreased to 10% to 25% of control values within 24 hr of CTX administration. This was followed by a recovery of spleen megakaryocytes and CFU-M to normal within 6 days, followed by a 24-fold increase above control values in spleen megakaryocytes and a 29-fold increase in spleen CFU-M. In contrast, recovery of megakaryocytes and CFU-M in the marrow was delayed for 2 weeks. An increase in marrow CFU-M above control values was not observed, although megakaryocytes increased to 150% of control. Granulocytes and their progenitor cells (CFU-GM) responded in a similar manner after CTX administration. These results indicate that blood platelet levels are only slightly decreased after a single injection of CTX whereas CFU-M and megakaryocytes are markedly decreased. The recovery and increased production of megakaryocytes and CFU-M in the face of a near-normal platelet level suggests that factors other than the platelet level are responsible for production of CFU-M and megakaryocytes.
    [Abstract] [Full Text] [Related] [New Search]