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Title: Pimozide-induced chronic hyperprolactinaemia and quantitative initiation of spermatogenesis in maturing rats. Author: Nag S, Sanyal S, Biswas NM. Journal: J Endocrinol; 1982 Oct; 95(1):13-8. PubMed ID: 7130887. Abstract: When pimozide was given to maturing rats, a rise in the level of prolactin in the serum was accompanied by a fall in LH. There was also incomplete initiation of spermatogenesis as well as simultaneous adrenal hypertrophy. Bilateral adrenalectomy failed to prevent hyperprolactinaemia-induced antispermatogenic response, while a significant ameliorating effect was observed with LH, indicating that hyperprolactinaemia influenced the quantitative initiation of spermatogenesis by affecting the secretion of LH.[Abstract] [Full Text] [Related] [New Search]