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  • Title: The effects of 2,5-hexane dione on remyelination in the peripheral nervous system of the mouse.
    Author: Hall SM, Gregson NA.
    Journal: J Neuropathol Exp Neurol; 1982 Nov; 41(6):642-51. PubMed ID: 7131041.
    Abstract:
    We compared the development and resolution of a demyelinating lesion (produced by the intraneural injection of lysophosphatidyl choline) in mice exposed to a known neurotoxic agent (2,5-hexane dione) with similar events in control animals. A prolongation of the pro-myelin stage was observed in the hexane dione-treated animals: the suppression of remyelination became progressively more marked with the length of exposure to hexane dione. Prolongation of the pro-myelin stage is an indication of a disturbance in some component of the complex interaction between Schwann cell and axon, and presumably reflects the neurotoxicity of 2,5-hexane dione.
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