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  • Title: Thermogenic response to glucagon in cold-acclimated mice.
    Author: Doi K, Kuroshima A.
    Journal: Jpn J Physiol; 1982; 32(3):377-85. PubMed ID: 7131937.
    Abstract:
    Heat production after injection of glucagon and norepinephrine was measured in warm- and cold-acclimated mice. Glucagon and norepinephrine in a dose of 100 microgram/100 g caused a marked increase in oxygen consumption. Heat production after administration of glucagon and norepinephrine was significantly potentiated by cold acclimation. A significant positive correlation was observed between the increase in oxygen consumption after injection of glucagon or norepinephrine and the weight of brown adipose tissue in warm- and cold-acclimated mice. These findings indicate that glucagon is a calorigenic hormone in mice and its effect is potentiated by cold acclimation possibly due to an activation of thermogenic mechanism(s) in brown adipose tissue.
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