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  • Title: Gliomas of the anterior visual pathway in children. Tumour behaviour and effect of treatment.
    Author: Gunnesson-Nordin V, Blennow G, Garwicz S, Brun AE, Bynke H, Landberg TG, Strömblad LG.
    Journal: Neuropediatrics; 1982 May; 13(2):82-7. PubMed ID: 7133327.
    Abstract:
    An analysis of 16 cases of optic glioma in childhood is presented. All tumours were astrocytomas of the juvenile pilocytic of type low malignancy. In 7 of 13 patients with involvement of the chiasm there was a significant progression of tumour during the follow-up period, including 4 cases with fatal outcome. Patients under 5 years of age had a more unfavourable course than older children, but at the same time they had received lower doses of radiotherapy. The 5 patients treated with an absorbed dose of 39 Gy or more are alive without signs of progression 7-20 years after treatment. It is concluded from this material and from a survey of literature that many cases of optic glioma in childhood do not have a benign course. Guidelines for treatment are proposed.
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