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  • Title: Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease.
    Author: Rothuizen J, van den Ingh TS.
    Journal: Res Vet Sci; 1982 Jul; 33(1):22-5. PubMed ID: 7134644.
    Abstract:
    An ammonia tolerance test (ATT) is described in control dogs and in patients affected by liver disease with or without portosystemic collateral circulation. The administration of a 5 per cent ammonium chloride solution rectally proved to be preferable to oral administration. A statistically significant difference was shown between the results of the ATT in patients with and those without portal shunts, but not between control dogs and patients without portal collateral circulation. A simplified ATT is proposed in which venous ammonia determinations are made before and 20 and 40 minutes after rectal administration of 5 per cent ammonium chloride solution at a dose of 2 ml/kg bodyweight.
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