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  • Title: Factor IX thrombogenicity: in vivo effects on coagulation activation and a case report of disseminated intravascular coagulation.
    Author: Small M, Lowe GD, Douglas JT, Forbes CD, Prentice CR.
    Journal: Thromb Haemost; 1982 Aug 24; 48(1):76-7. PubMed ID: 7135346.
    Abstract:
    An episode of defibrination with bleeding following high dose Edinburgh Factor IX (D.E.F.IX) replacement in a patient with haemophilia B undergoing knee joint replacement is reported. We have also monitored plasma fibrinopeptide A levels in patients with haemophilia B following ten standard doses of D.E.F.IX (15-20 u/kg) and have been unable to document any change. Activation of the coagulation system, as previously noted, appears to be related to the use of Factor IX concentrates in high doses.
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