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Title: Selective arterial medial injury fails to produce intimal hyperplasia in experimental animals. Author: Spaet TH, Tiell ML, Cintron J, Won J. Journal: Thromb Res; 1982 Jul 15; 27(2):205-10. PubMed ID: 7135355. Abstract: The hypothesis was tested, in rats and rabbits, that selective medial injury may lead to arterial intimal hyperplasia. Lesions were produced by passage of a micro-suture through the arterial wall without penetration to the lumen, or controls in which the suture did penetrate. Vessels were examined histologically at intervals up to 2 weeks after suturing. Only vessels with penetrating sutures developed intimal hyperplasia, suggesting that medial injury alone is insufficient for the production of arteriosclerosis.[Abstract] [Full Text] [Related] [New Search]