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  • Title: [Population kinetics of microcolonies causing "shouldered" survival curves at low LET].
    Author: Harder D, Virsik P.
    Journal: Strahlentherapie; 1982 Jul; 158(7):440-3. PubMed ID: 7135441.
    Abstract:
    The well-known fact that the dose dependence of cell survival, when measured by the macrocolony-forming test, can be fitted with the multitarget expression is re-investigated by considering the delayed loss of cellular reproductivity in a microcolony. As the reproductive capacity of each single cell of the microcolony must be lost in order to prevent the development of a macrocolony, the reproductive death of a microcolony is in mathematical analogy to the multitarget model and provides the biological explanation for its formal applicability. Published data from colony-size distributions and the model of "latent genetical damage" are utilized to understand the exponential dose dependence of single cell survival in a microcolony. Exponential survival curves obtained at high LET are explained by an undelayed loss of reproductivity in the irradiated cell. The restitution of the "shoulder" in delayed-plating and split-dose experiments is interpreted by repair effects.
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