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  • Title: [Formation of aberrant polyploid hepatocytes in exposure to the alkylating preparation dipin and to stimulation of proliferation].
    Author: Uryvaeva IV, Faktor VM.
    Journal: Tsitologiia; 1982 Aug; 24(8):911-7. PubMed ID: 7135484.
    Abstract:
    One month after the treatment of mice with the alkylating drug Dipin followed by partial hepatectomy 4.7--35.1% of hepatocytes with micronuclei and nuclear bridges in liver were registered. The ploidy level sharply increased. Aberrant cells were the most polyploid ones (16c, 32c). The DNA-fuchsin content in these aberrant polypolid cells decreased by 10--15% due to degrading and non-replication of DNA in the micronuclei.
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