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  • Title: Inhibition of tissue aryl hydrocarbon (benzo[a]pyrene) hydroxylase by 7,8-benzoflavone in birds.
    Author: Husain MM, Kumar A, Mukhtar H.
    Journal: Xenobiotica; 1982 Jun; 12(6):375-80. PubMed ID: 7136005.
    Abstract:
    1. Addition of 7,8-benzoflavone (7,8-BF) inhibited both hepatic and renal constitutive activity of aryl hydrocarbon (benzo[a]pyrene) hydroxylase in vitro for a number of avian species. Inhibition of hepatic benzo[a]pyrene hydroxylase was 70-94% in wild pigeon; 46-88% in homing pigeon; 85-93% in house crow; 18-53% in common kite; 56-86% in cattle egret; and for the renal enzyme was 43-84, 52-88, 18-73 and 13-48% respectively. 2. 3-Methylcholanthrene treatment of homing pigeons resulted in the induction of liver and kidney benzo[a]pyrene hydroxylase activity. Induced enzyme activity was also significantly inhibited by 7,8-BF.
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