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  • Title: Medullary carcinoma of the thyroid with ectopic ACTH syndrome.
    Author: Kakudo K, Miyauchi A, Ogihara T, Takai S, Kitamura H, Kumahara Y, Kawaoi A.
    Journal: Acta Pathol Jpn; 1982 Sep; 32(5):793-800. PubMed ID: 7136694.
    Abstract:
    An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke's degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, beta-MSH as well as calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discussed.
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