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  • Title: Regulation of subcutaneous blood flow during head-up tilt (45 degrees) in normals.
    Author: Skagen K, Bonde-Petersen F.
    Journal: Acta Physiol Scand; 1982 Jan; 114(1):31-5. PubMed ID: 7136743.
    Abstract:
    Local and remote regulation of subcutaneous blood flow in the forearm and leg was studied during head-up tilt (45 degrees) in 6 young healthy male subjects. Relative blood flow was estimated by the local 133Xe washout technique. Lowering of a leg to a 51% decrease in its subcutaneous blood flow due to a veno-arteriolar reflex elicited by the increase in venous transmural pressure. During head-up tilt subcutaneous blood flow in the arm remaining at heart level decreased by 27%, in the leg blood flow decreased by 50%. Following proximal nervous blockade, head-up tilt did not induce vasoconstriction in forearm at heart level, but blood flow in distal leg decreased by 45%. Thus there was no difference in the vasoconstrictor response in the leg to head-up tilt or lowering of the labelled area by 40 cm. Since head-up tilt caused neurogenically mediated vasoconstriction in subcutaneous tissue, subcutaneous blood flow in the extremities seems to be regulated by remote (baroreceptor) as well as local sympathetic reflex mechanisms (veno-arteriolar reflex).
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