These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine).
    Author: Chan AC, Pritchard ET, Gerrard JM, Man RY, Choy PC.
    Journal: Biochim Biophys Acta; 1982 Oct 14; 713(1):170-2. PubMed ID: 7138896.
    Abstract:
    The modulation of rat platelet phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) and rat platelet aggregation by mepacrine was investigated. The 2-acyl specificity of phospholipase A2 activity was confirmed by using 1-[14C]palmitoyl-2-[3H]arachidonylphosphatidylcholine as substrate. Under optimal pH, phospholipase A2 activity was not affected by aspirin but was inhibited by indomethacin. Contrary to previous reports, a biphasic modulatory role of mepacrine on phospholipase A2 activity and platelet aggregation was demonstrated. The data suggest that platelet aggregation is mediated via phospholipase A2.
    [Abstract] [Full Text] [Related] [New Search]