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  • Title: [Effect of triterpene glycosides on the stability of bilayer lipid membranes, containing different sterols].
    Author: Popov AM, Rovin IuG, Anisimov MM, Likhatskaia GN, Strigina LI.
    Journal: Biofizika; 1982; 27(5):827-31. PubMed ID: 7138933.
    Abstract:
    Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C sharply change the stability of bilayer lipid-sterine membranes. The glycosides activity decreases in the line: holothurin A, stichoposide A, cauloside C. The effective doses of glycosides are to a great extent determined by structural peculiarities of sterines which compose the films. A correlation was observed between the effect of triterpene glycosides on the stability of model bilayer membranes and their physiological activity. The model lipid-sterine membranes can be used in the primary screening of triterpene glycosides to estimate their physiological activity.
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