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  • Title: The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro.
    Author: Peatfield AC, Piper PJ, Richardson PS.
    Journal: Br J Pharmacol; 1982 Nov; 77(3):391-3. PubMed ID: 7139193.
    Abstract:
    We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.
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