These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Development of inhibitory activity of sulpiride for synaptic [3H]-spiperone binding in the rat striatum.
    Author: Oki K, Nomura Y.
    Journal: Dev Neurosci; 1982; 5(4):379-84. PubMed ID: 7140585.
    Abstract:
    To establish the functional development of striatal dopamine2 (DA2) receptors, the effects of NA+ and GTP on the potency of sulpiride in competing for specific [3H]-spiperone binding were investigated in the striatum of developing rats. The IC50 value of sulpiride for specific [3H]-spiperone binding was 31-fold decreased by 100 mM Na+ compared to that in 70-day-old control animals but not by 50 microM GTP. In the presence of Na+, the IC50 of sulpiride was low in fetuses at 18 days of gestation and high at 360 days of postnatal life. It is suggested that the Na+-dependent binding of sulpiride to DA2 receptors probably reaches functional maturity in fetuses at 18 days of gestation and that the Na+ dependence of the effect decreases during aging.
    [Abstract] [Full Text] [Related] [New Search]