These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Role of cholinergic mechanisms in the action of sodium oxybutyrate on the structures of the hippocampus-reticular complex and of the neocortex].
    Author: Krauz VA, Mamchur VI.
    Journal: Farmakol Toksikol; 1982; 45(5):27-31. PubMed ID: 7140951.
    Abstract:
    It has been established in chronic experiments on rabbits that accumulation of endogenous acetylcholine (galanthamine--1 mg/kg) prevents the development of sodium hydroxybutyrate (500 mg/kg) ability to increase the excitability of the mesencephalic reticular formation and to reduce the level of frontal cortex excitability. Inhibition of the central muscarinic (metamizyl--2 mg/kg) or nicotinic (eterofen--10 mg/kg) cholinoreceptors prevents the stimulant action or sodium hydroxybutyrate on the excitability of the dorsal hippocamp and mesencephalic reticular formation. Blockade of the central N-cholinoreceptors changes the marked effect of sodium hydroxybutyrate on the blood content of the test brain structures. This may attest to the participation of N-cholinoreceptors in the effects of sodium hydroxybutyrate.
    [Abstract] [Full Text] [Related] [New Search]