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  • Title: [Effect of nonachlazine on the energy provision for cardiac contractile activity in experimental myocardial infarct].
    Author: Reznikov KM, Provotorova PP, Sidel'nikova VI.
    Journal: Farmakol Toksikol; 1982; 45(5):52-7. PubMed ID: 7140956.
    Abstract:
    Experiments on 107 rabbits and 76 white rats with the use of electrophysiological, biochemical and electron microscopy research methods have shown that nonachlazine-induced improvement of heart contractility in microfocal myocardial infarction occurs as a result of the shortening of the systolic and lengthening of the diastolic phases of the heart cycle. Nonachlazine improves the processes of oxidative phosphorylation in heart mitochondria in myocardial infarction, which is accompanied by inhibition of the activity of succinate dehydrogenase and transition of oxidation from succinate to NAD-dependent substrates.
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