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  • Title: Endogenous synthesis of volatile nitrosamines: model calculations and risk assessment.
    Author: Fine DH, Challis BC, Hartman P, Van Ryzin J.
    Journal: IARC Sci Publ; 1982; (41):379-96. PubMed ID: 7141545.
    Abstract:
    A kinetic model for estimating the gastric synthesis of N-nitroso compounds and a method for estimating the risk from exposure to volatile nitrosamines are described. A tentative calculation of the possible risks for human gastric cancer, based on extrapolating from literature data on the induction of tumours in rats, suggests that the endogenous formation of non-volatile N-nitroso compounds is more important than that of volatile nitrosamines.
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