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  • Title: [Pharmacokinetic and clinical research on a new aminoglycoside antibiotic: sisomicin].
    Author: Di Nola F, Soranzo ML, Bosio G, Sachelariu N, Guasco C, Bendiscioli L, Bisarello I.
    Journal: Minerva Med; 1978 Sep 19; 69(43):2951-62. PubMed ID: 714275.
    Abstract:
    Results obtained with sisomycin in 10 cases of purulent meningitis and 4 of bronchopulmonitis showed good tissue diffusion, together with CSF concentrations sufficient to inhibit the main aetiological agents in these forms: MIC 0.02 mg/ml for both D. pneumoniae (I-ATCC 6301) and N. meningitidis (C-ATCC 13101), i.e. liquor transfer of the antibiotic more than sufficient to handle these agents.
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