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  • Title: Rat adjuvant arthritis as a model to test potential antirheumatic agents.
    Author: Toivonen ML, Tokola O, Vapaatalo H.
    Journal: Methods Find Exp Clin Pharmacol; 1982; 4(6):359-63. PubMed ID: 7144330.
    Abstract:
    Adjuvant arthritis was induced in male Sprague-Dawley rats by a subcutaneous injection of Mycobacterium tuberculosis in sterile paraffine oil into the base of the tail. The effects of the immunomodulating drugs N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium (CCA), d-penicillamine and thiabendazole were compared to those of the anti-inflammatory drugs indomethacin, tolfenamic acid and prednisolone. All the anti-inflammatory drugs were highly protective. Of the immunomodulating drugs thiabendazole also showed dose-related inhibitory effect. CCA had only a negligible effect and d-penicillamine enhanced the activity of the arthritic syndrome. An aggravation of the arthritis also occurred after pretreatment with d-penicillamine for 30 days before the induction of arthritis. The complement inhibiting agents epsilon aminocaproic acid and heparin enhanced the symptoms of the adjuvant arthritis as did d-penicillamine. We suggest that the effects of the immunomodulating drugs are dependent on the dose used and the stage of the disease at the beginning of treatment.
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