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  • Title: [On the polymorphism of barbiturates in powders and tablets. 6: Properties and behaviour of a spray-dried barbital preparation].
    Author: Matzkó-Hollenbach K, Pintye-Hódi K, Kedvessy G.
    Journal: Pharmazie; 1982 Aug; 37(8):562-5. PubMed ID: 7146063.
    Abstract:
    The manufacture of a spray-dried barbital preparation is described, the properties, tabletting behaviour and release of which were studied in comparison to the initial substance. Spray-drying led to a compression-resistant mixture of amorphous and crystalline particles. As most of these particles have a spherical shape, the tablets obtained from this mixture were of great compactness, which inhibited the penetration of the medium and, consequently, delayed the release of the drug, too.
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