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  • Title: [Crabtree effect caused by ketoses in isolated rat hepatocytes].
    Author: Martínez P, Carrascosa JM, Núñez de Castro I.
    Journal: Rev Esp Fisiol; 1982; 38 Suppl():181-3. PubMed ID: 7146574.
    Abstract:
    Oxygen uptake and glycolytic activity were studied in hepatocytes isolated from fed rats. The addition of fructose or tagatose resulted in a 38% and 31% inhibition of cellular respiration respectively. The addition of 10 mM D-glyceraldehyde caused a slight Crabtree effect. Glucose, L-sorbose, or glycerol failed to modify oxygen consumption. Only incubation in the presence of fructose showed a high aerobic glycolysis measured by lactate production.
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