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Title: Transient Raman study of hemoglobin: structural dependence of the iron-histidine linkage. Author: Friedman JM, Rousseau DL, Ondrias MR, Stepnoski RA. Journal: Science; 1982 Dec 17; 218(4578):1244-6. PubMed ID: 7146910. Abstract: Low-frequency resonance Raman spectra of transient hemoglobin species were observed within 10 nanoseconds of photolysis. The Raman frequencies of the iron-proximal histidine stretching mode for transient species having either the R or the T quaternary structure are higher than in the corresponding deoxy species. The observed frequency difference in the iron-histidine mode between the R- and T- state transients indicates that there are quaternary structure-dependent protein forces on the iron-histidine bond in the liganded hemoglobins. These differences are interpreted in terms of changes in the tilt of the histidine with respect to the heme plane.[Abstract] [Full Text] [Related] [New Search]