These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Thymidine kinase activity in mammary tumors of animals exposed to estradiol as an index of tumor hormone dependence].
    Author: Morozova TM, Plotnikova LIa.
    Journal: Vopr Onkol; 1982; 28(11):58-62. PubMed ID: 7147834.
    Abstract:
    The effects of ovariectomy and estrogen treatment on the activity of thymidine kinase in estrogen-dependent and estrogen-independent mammary gland tumors (MGT) of experimental animals were studied. Thymidine kinase activity decreased 3-18 fold after ovariectomy in estrogen-dependent MGT only. It increased 3-7 fold again after estradiol treatment. These changes were significantly greater than those in hexokinase and glucose-6-phosphate dehydrogenase activity. High doses of estrogens (200 micrograms/day) resulted in an 1.8-3.5-fold decrease in thymidine kinase in estrogen-dependent MGT. The enzyme activity in estrogen-independent MGT did not change. It is suggested to use thymidine kinase activity as a marker of proliferative processes in evaluation of hormone-dependency of tumors and the effects of other factors on tumor growth.
    [Abstract] [Full Text] [Related] [New Search]