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  • Title: Effects of repeated injections of naltrexone on antagonism of rate decreases by morphine in the pigeon.
    Author: Smith JB.
    Journal: Pharmacol Biochem Behav; 1978 Aug; 9(2):265-7. PubMed ID: 714975.
    Abstract:
    Responding of three pigeons was maintained under a multiple schedule of food presentation in which key-pecks produced access to grain under a fixed-interval schedule in the presence of one stimulus and a fixed-ratio schedule in the presence of another stimulus. Repeated daily injections of 1 mg/kg naltrexone had no systematic effect on overall response rate during either schedule component, and the naltrexone continued to antagonize rate decreases of periodic single injections of 10 mg/kg morphine for seven weeks. Tolerance did not occur to the antagonistic effects of naltrexone on rate decreases generally produced by morphine.
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