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  • Title: [Analysis of the mechanisms of effect of beta/gamma-thrombin on the state of the anticoagulating system].
    Author: Semenova OA, Umarova BA, Strukova SM, Kudriashov BA.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1982 Nov; 68(11):1526-30. PubMed ID: 7152054.
    Abstract:
    A 75-min perfusion of the rabbit humorally isolated carotid sinus with intact innervation with the beta/gamma-thrombin in concentrations of 2.9 X 10(7) M and 8.8 X 10(-7) M did not alter normal values of total and non-enzymatic fibrinolysis or plasma recalcification time in the systemic blood stream. Hence, beta/gamma-thrombin differs from alpha-thrombin in its inability to stimulate chemoreceptors of the carotid sinus which suggests a major part of the additional area for binding macromolecular substrates played in the thrombin interaction with vascular wall's chemoreceptors. I. V. administration of 2.1 X 10(-6) M beta/gamma-thrombin induces in rats a considerable increase of the soluble fibrin: 9.4-fold within the 1st min and 4.5-fold by the 5th min which suggests a generation of endogenous alpha-thrombin in the blood stream. This process maintains the activation of anticoagulating system occurring after the i. v. beta/gamma-thrombin administration.
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