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  • Title: [Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical studies].
    Author: Liebich HG, Mertin J, Seifert J.
    Journal: Fortschr Med; 1982 Nov 04; 100(41):1922-5. PubMed ID: 7152425.
    Abstract:
    In animal experiments marked and characteristic changes of lymphocytes could be observed with electronmicroscopic methods due to aldosterone and potassium canrenoate. These results may be a further reference to an immunosuppressive effect of aldosterone and spirolactone derivates. The electronmicroscopic study of thoracic duct cells of a patient suffering from multiple sclerosis and treated with aldosterone and potassium canrenoate showed changes of the morphological structure of small lymphocytes, which was interpreted with a lymphoclastic effect of this substances on lymphocytes.
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