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  • Title: Determination of salbutamol in human plasma with bimodal high-performance liquid chromatography and a rotated disc amperometric detector.
    Author: Oosterhuis B, van Boxtel CJ.
    Journal: J Chromatogr; 1982 Nov 12; 232(2):327-34. PubMed ID: 7153280.
    Abstract:
    The sensitivity of electrochemical detection was combined with the selectivity of a bimodal high-performance liquid chromatographic system for the successful determination of salbutamol in human plasma. Following initial sample clean-up using Sep-Pak cartridges, analytes were passed first through a cation-exchange column, and then, after column switching, through a reversed-phase column. An amperometric detector with a rotated disc working electrode was used for detection. The detection limit was 0.5 ng/ml when 1.0 ml of plasma was used. The coefficient of variation was 9.8% at an average concentration of 4.7 ng/ml. The method was adequate for pharmacokinetic studies and for clinical applications.
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