These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Assignment of ADA, ITPA, AK1, and AK2 to Chinese hamster chromosomes. Genetic and structural evidence for the conservation of mammalian autosomal synteny.
    Author: Stallings RL, Siciliano MJ.
    Journal: J Hered; 1982; 73(6):399-404. PubMed ID: 7153494.
    Abstract:
    Interspecific somatic cell hybrids formed by fusion of mouse Cl1D cells with Chinese hamster primary spleen or fibroblast cells were used to form a clone panel with members retaining different combinations of Chinese hamster chromosomes and isozyme markers. Concordant segregation analysis of isozymes and chromosomes among clone panel members enabled the provisional assignment of ADA, ITPA, and AK1 to Chinese hamster chromosome 6. Diphtheria toxin selection for Chinese hamster chromosome 2 segregants in Dede cell X Cl1D somatic cell hybrids indicated AK2 is located on chromosome 2. These assignments extend observations of autosomal linkage group conservation in mammals--a concept further supported by similarity of G-band patterns in certain chromosomal regions bearing homologous loci in Chinese hamsters, humans, and mice.
    [Abstract] [Full Text] [Related] [New Search]