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  • Title: Naloxone decreases consumption of liquid and solid sucrose in vagotomized rats.
    Author: Clarkson DB, King BM, Hemmer RC, Olson GA, Kastin AJ, Olson RD.
    Journal: Physiol Behav; 1982 Nov; 29(5):927-30. PubMed ID: 7156230.
    Abstract:
    Intraperitoneal injections of the opiate antagonist naloxone decreased food intake in both vagotomized and sham-vagotomized rats. Consumption of liquid and solid sucrose, which were used in order to equate baseline intake, was equally suppressed in both groups under food-deprivation and appetitively-motivated conditions at all doses of naloxone (1, 2, 4, and 8 mg/kg). It is concluded that, in contrast to previous findings, the vagus nerve does not mediate the suppressive effects of naloxone on feeding behavior.
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