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  • Title: Familial antithrombin III deficiency.
    Author: Winter JH, Fenech A, Ridley W, Bennett B, Cumming AM, Mackie M, Douglas AS.
    Journal: Q J Med; 1982; 51(204):373-95. PubMed ID: 7156320.
    Abstract:
    Antithrombin III is the major physiological inhibitor of the coagulation mechanism and a deficiency of this protein results in a marked predisposition to venous thromboembolic disease. Three Scottish families with a deficiency of this protein are described and other reported families are reviewed. The properties, functions and methods of assay of antithrombin III are outlined; the molecular abnormalities, inheritance, clinical and laboratory characteristics of antithrombin III deficiency are described, and the use of antithrombotic drugs and human antithrombin III concentrates in this deficiency is discussed.
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