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  • Title: Evolution of cadmium-induced renal dysfunction in workers removed from exposure.
    Author: Roels H, Djubgang J, Buchet JP, Bernard A, Lauwerys R.
    Journal: Scand J Work Environ Health; 1982 Sep; 8(3):191-200. PubMed ID: 7156938.
    Abstract:
    A retrospective examination of the medical records gathered during several surveys carried out among cadmium workers has permitted the identification of a group of 19 workers who had been examined before and after removal from cadmium exposure. All the workers had been exposed for more than 15 a (range 15.6-41.7 a). Their last examination took place from 0.3 to 7.9 a after the date of removal from cadmium exposure. At that time, all the workers exhibited sign(s) of cadmium-induced renal dysfunction. Comparison of the renal function parameters (serum creatinine, total proteinuria, aminoaciduria, albuminuria, beta 2-microglobulinuria, and the urinary excretion of retinol-binding protein) before and after the cessation of exposure indicated that cadmium-induced renal lesions, albeit of slow progression, are not reversible when exposure ceases.
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