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  • Title: Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2.
    Author: Bonner JJ, Tyan ML.
    Journal: Teratology; 1982 Oct; 26(2):213-6. PubMed ID: 7157197.
    Abstract:
    Data in this report demonstrate a linkage between glucocorticoid-induced cleft palate susceptibility and H-2. B10.A X C57BL/10F1 females were backcrossed to C57BL/10 males. Cleft palate was induced in the BC1 fetuses by giving pregnant females 80 mg/kg of dexamethasone intraperitoneally (IP) on day 12 of gestation. The H-2a/b haplotype was detected on day 18 BC1 fetal spleen cells with an indirect immunofluorescent labeling technique. Fetuses without antigen H-2Kk were H-2b/b . H-2a/b fetuses had a cleft palate frequency of 29%; 11% of the H-2b/b fetuses had cleft palate (P less than .01), demonstrating that the higher susceptibility to cleft palate segregates with the H-2a halotype.
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