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  • Title: [Induction of DNA reparative synthesis and the toxic effects of carcinogens in embryonic cell cultures].
    Author: Budunova PV, Belitskiĭ GA.
    Journal: Tsitologiia; 1982 Dec; 24(12):1450-4. PubMed ID: 7157473.
    Abstract:
    The carcinogens used in this work were divided into two groups according to their ability to induce DNA repair synthesis in embryonic cell cultures: powerful inducers (UV-light; N-methyl-N'-nitro-N-nitrosoguanidine; 4-nitroquinoline-1-oxide) and weak inducers (aflatoxin B1; 7,12-dimethylbenz(a)anthracene). In contrast to the latter, the former were found to be strong inhibitors of DNA replicative synthesis. To induce the active DNA repair synthesis, it is necessary to use toxic concentrations of the carcinogens examined.
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