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  • Title: Comparison of metronidazole with clindamycin-gentamycin combination in the prevention of infectious complications after elective colonic surgery.
    Author: Huttunen R, Laitinen S, Mokka R, Ståhlberg M, Kairaluoma M, Herva E, Larmi TK.
    Journal: Ann Chir Gynaecol; 1982; 71(6):317-20. PubMed ID: 7159001.
    Abstract:
    The efficacy of metronidazole, active only against anaerobes, and clindamycin-gentamycin combination, covering both anaerobes and aerobes, in the prevention of infectious complications after elective colonic surgery was compared in a prospective randomized trial over a three-year period. A total of 130 patients were accepted for the trial, 67 receiving metronidazole intrarectally and 63 receiving clindamycin-gentamycin combination. The prophylactic treatment was started on the evening before the operation and continued for 24 hours. One patient out of 67 receiving metronidazole (1.5%) and two patients out of 63 receiving clindamycin-gentamycin (3.2%) developed a wound infection. An intra-abdominal infection occurred in two patients in both groups (3% and 3.2%, respectively). There was no statistically significant difference in postoperative infections between the groups. The authors conclude that metronidazole is as effective as the clindamycin-gentamycin combination and should be preferred to broad-spectrum antibiotics because of its fewer side effects and lower potential of developing resistant bacterial strains.
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