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  • Title: Inhibitory effect of betahistine on polysynaptic neurons in the lateral vestibular nucleus.
    Author: Unemoto H, Sasa M, Takaori S, Ito J, Matsuoka I.
    Journal: Arch Otorhinolaryngol; 1982; 236(3):229-36. PubMed ID: 7159275.
    Abstract:
    Effects of betahistine, an antivertigo drug, were examined on the lateral vestibular nucleus (LVN) neurons of cats anesthetized with alpha-chloralose. Spike generation of monosynaptic LVN neurons elicited by vestibular nerve stimulation remained unaffected with intravenous administration of betahistine up to 5 mg/kg and with iontophoretic application of the drug up to 200 nA. In contrast, the spike generation of polysynaptic I neurons in the LVN was dose-dependently inhibited by intravenous as well as iontophoretic application of betahistine. These results suggest that small doses of betahistine more selectively interfere with synaptic transmission in the polysynaptic I neurons than in the monosynaptic neurons.
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