These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Evidence against co-storage of enkephalins with noradrenaline in bovine adrenal medullary granules.
    Author: Lang RE, Taugner G, Gaida W, Ganten D, Kraft K, Unger T, Wunderlich I.
    Journal: Eur J Pharmacol; 1982 Dec 17; 86(1):117-20. PubMed ID: 7160428.
    Abstract:
    Bovine adrenal chromaffin granules were purified and separated into adrenaline (A) and noradrenaline (NA) containing granule populations by a combination of differential and isopycnic gradient centrifugation. The distribution of [Leu5]enkephalin as measured by radioimmunoassay followed a pattern identical to adrenaline but not noradrenaline on centrifugation. This suggests that enkephalins are stored in the same type of granule where adrenaline is found or that enkephalins and adrenaline even coexist in one and the same granule. Enkephalins may therefore function as co-transmitters or co-hormones of adrenaline rather than noradrenaline in the adrenal medulla.
    [Abstract] [Full Text] [Related] [New Search]