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  • Title: Effect of different levels of vitamin B6 in the diet of rats on the content of pyridoxamine-5'-phosphate and pyridoxal-5'-phosphate in the liver.
    Author: van den Berg H, Bogaards JJ, Sinkeldam EJ, Schreurs WH.
    Journal: Int J Vitam Nutr Res; 1982; 52(4):407-16. PubMed ID: 7160968.
    Abstract:
    The pyridoxal-5'-phosphate (PLP) and pyridoxamine-5'-phosphate (PMP) contents were determined in livers of rats fed diets containing different levels of vitamin B6 (0.3-22.9 ppm). Maximum growth was attained at vitamin B6 intake levels of greater than or equal to 24 micrograms/day. Maximum PLP and PMP levels in a crude liver homogenate were reached at intake levels of 75 and 9 micrograms/day respectively. In the 100 000 g supernatant fraction of liver the maximum PLP level was reached at intake levels of greater than or equal to 37 micrograms/day. The PLP/PMP-ratio of the crude liver homogenate increased from 0.6 up to values of appr. 1.5 at the higher intake levels. The PLP/PMP-ratio in the 100 000 g supernatant was more variable and did not show a consistent trend at varying vitamin B6 intakes.
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