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  • Title: Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin.
    Author: Fukushima K, Arai T, Iwasaki S, Namikoshi M, Okuda S.
    Journal: J Antibiot (Tokyo); 1982 Nov; 35(11):1480-94. PubMed ID: 7161187.
    Abstract:
    Skeletal structure of copiamycin (1) (C54H95N3O17), a potent antifungal antibiotic, was determined from the physicochemical properties of this compound and of its degradation products. This compound consists of 32-membered polyhydroxy lactone ring, an alpha, beta-unsaturated ester group, as well as a side chain with a disubstituted guanidine moiety as its terminal. One of the hydroxyl groups (presumably at C-19) forms a hemiketal ring with the keto group at C-15, and another (at either C-21 or C-23) forms a hemiester with a malonic acid moiety.
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