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  • Title: Cortisol suppression index: a new approach to interpreting the DST in depression.
    Author: Bernstein JP, Chung SY, Avila KS.
    Journal: J Clin Psychiatry; 1982 Dec; 43(12):476-8. PubMed ID: 7161249.
    Abstract:
    The cortisol suppression index (CSI) is a ratio of pre- to postdexamethasone plasma cortisol concentrations. In a sample of 24 psychiatric inpatients, an 8 a.m. CSI detected 66% of patients with major depression. Further studies with larger samples and additional controls, including normal subjects, are suggested to validate these prospective findings. This index may serve as a useful and more practical way of detecting major depression in outpatients.
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